Smad proteins are the intracellular mediators of the transforming growth factor beta (TGF-b) superfamily. My laboratory will be focusing on role of Smad genes in the control of mammalian development, disease, and cancer using primarily knockout and transgenic mice. Our research has shown that Smad2 and Smad 4 are required for gastrulation, while Smad5 is involved in angiogenesis and crainiofacial development. Smad3 appears to mediate mucosal immunity. Ongoing studies are underway to pinpoint functions of other Smad genes in mammalian development and cancer.
Debies M, Waters W, Taffany D, Spahich N, Festing M, Weinstein M. 2007. SARA, a FYVE Domain Containing Protein Linked To TGF-ÃŸ Signaling, Is Not Required For Murine Viability and Fertility. Mol Cell Biol. under revision.
Liu Y, Lasse S, Bail S,Thompson JC, Kiledjian M, Weinstein M. 2007. Smif/Dcp1a, a constituent of mRNA decapping complexes also thought to function in TGFb signaling, is essential for mammalian placentogenesis. Dev Biol. Submitted.
Pavel E, Zhao W, Powell KA, Weinstein M, Kirschner LS. 2007. Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region. Int J Dev Biol. 51(4):273-81.
Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS, Guttridge DC. 2007. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest. Apr;117(4):889-901.
Dorrance AM, Liu S, Yuan W, Becknell B, Arnoczky KJ, Guimond M, Strout MP, Feng L, Nakamura T, Yu L, Rush LJ, Weinstein M, Leone G, Wu L, Ferketich A, Whitman SP, Marcucci G, Caligiuri MA. 2006. Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest. 116(10):2707-16.
Yu J, Wei M, Becknell B, Trotta R, Liu S, Boyd Z, Jaung MS, Blaser BW, Sun J, Benson DM Jr, Mao H, Yokohama A, Bhatt D, Shen L, Davuluri R, Weinstein M, Marcucci G, Caligiuri MA. 2006. Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells. Immunity. 24(5):575-90.
Weinstein, M., and Deng, C. X. 2006. Genetic disruptions within the murine genome reveal the numerous roles of the Smad gene family in development, disease, and cancer. Smad signal Transduction: Smads in proliferation, differentiation and disease (Dordrecht, Springer). Editors: Ten Dijke, P. and Heldin, Carl-Henrik. Vol 5, Chapter 8, 151-176.