Well deserved congratulations to Dr. Ruben Petreaca, whose NCI grant entitled "The role of chromatin remodeling factors in DNA double strand break repair" was recently funded. Working with co-Investigators Renee Bouley and Ryan J. Yoder, this grant will examine the importance of DNA damage repair in cancer. One challenge to understanding the genetic change in cancer cells is the complexity of the different processes that participate in DNA damage repair. Errors in some of these repair processes cause accumulation of various forms of DNA damage that eventually leads to cellular transformation and cancer. This grant propose novel protein modeling and genetic analysis experiments to study the interplay among the various DNA damage repair factors.